The pregnane x receptor
WebbThe Pregnane X Receptor. Pregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating … Webb1 dec. 1999 · Two of these sites, FP3 (bases -7738 to -7715) and FP4 (bases -7698 to -7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). …
The pregnane x receptor
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Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … WebbPregnane X receptor (PXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of …
Webb13 mars 2024 · Nuclear factor erythroid 2-related factor 2 (Nrf2) and pregnane X receptor (PXR) are important transcriptional factors that regulate the expression of anti-genotoxic phase II detoxification enzymes and phase III transporters [ 18, 19, 21, 22, 23 ]. Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory …
Webb15 okt. 2024 · Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is … WebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 …
WebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly …
WebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains … cannot convert type string to datetime c#WebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and … cannot convert undefined to booleanWebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders. cannot convert value of type array to integerWebbPregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer … cannot convert type bool to inthttp://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh fj cruiser rear door rattleWebb29 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily [].As part of the … fj cruiser rear hatchWebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse … fj cruiser rear bumper oem