Phosphopantetheine-binding protein
WebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4′-phosphopantetheine (4′-PP) cofactor, ACPM is involved in mitochondrial fatty acid synthesis and lipoic acid biogenesis. Recently, yeast A Molecular Pharmacology WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl …
Phosphopantetheine-binding protein
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WebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ... WebOct 15, 2012 · Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway. ... PHOSPHOPANTETHEINE BINDING PROTEIN; Organism(s): Acinetobacter baumannii AB307-0294; ... Phosphopantetheine attachment site family protein: A, B: 88: …
WebAug 31, 2015 · In vitro experiments have shown that in addition to vitamin B5, pantetheine can also be phosphorylated by pantothenate kinase activity, and the formed product, 4′-phosphopantetheine, can serve as... WebFeb 9, 2024 · Binding poses of the natural substrates 4′-phosphopantetheine (PPSH) and ATP are shown for comparison. C) Hydrogen-bonding interactions and hydrophobic interactions (HI) (both represented by dashed lines) between benzophenone 6 and Mtb PPAT. D) Conformational changes observed upon binding of benzophenone 6 to Mtb PPAT.
WebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation WebLegend. Settings. Analysis
WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl …
WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … bind shell backdoor detection fixWebJan 18, 1999 · Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide-binding fold that is structurally similar to that in class I aminoacyl-tRNA synthetases. Superposition of bound adenylyl moieties from dPCoA in PPAT and ATP in aminoacyl-tRNA synthetases suggests nucleophilic attack by the 4'-phosphopantetheine … bind shift +speed r_cleardecalsWebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement … bind shell payloadWebphosphopantetheine-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002376; WP_010369400.1; 206556 - 208052 (+) AMP-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002381; WP_010369404.1; 208045 - 210228 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein: copy AA seq cyte covid testingWebAlthough holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al.in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. bind shift +speedWebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA. cyted loginWebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. cyte cyto meaning