Effect of etoricoxib on the heart of rat
WebBackground: Neuregulin (NRG-1), an essential stress-mediated paracrine growth factor, has a cardioprotective effect in failing heart. However, the underlying mechanism remains unclear. The role of NRG-1β in heart failure (HF) rats was examined. Methods and Results: Volume-overload HF rat model was created by aortocaval fistula surgery. The sham … WebSep 1, 2007 · Treatment with etoricoxib, misoprostol, and etoricoxib combined with misoprostol inhibited the inflammation process by 35 %, 30 %, and 61 %, respectively in the rat paw edema induced by...
Effect of etoricoxib on the heart of rat
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Anti-inflammatory painkillerslike etoricoxib are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Etoricoxib eases pain and swelling (inflammation) in conditions like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, and it may … See more Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start … See more Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common … See more WebNov 24, 2024 · In the light of the aforementioned by Faour et al, 20 the purpose of the current study is to evaluate the chronic efficacy and safety profile of two bipyrazole compounds previously demonstrated to have a good acute anti-inflammatory effect. Based on the probit method, doses were determined to assess the chronic anti-inflammatory …
WebSep 29, 2024 · Cisplatin (CP) is one of the most active medications in cancer treatment and has some adverse effects such as hepatotoxicity and nephrotoxicity. The present research was planned to determine the … WebSep 30, 2011 · Administration of Etoricoxib (3 and 10 mg/kg i.p.) significantly (P < 0.01) reduced mortality in focally ischemic rats to 10% and 20% (Fisher's exact test), respectively. However at 1 mg/kg dose a higher mortality (40%) was observed (Fig. 1A). Effect of Etoricoxib on brain infarct volume after tMCAO in rats
WebObjective: This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver. Material and methods: Experimental animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG). ETO-50 and ETO-100 ... WebInhibitors of cyclooxygenase (COX) have a protective effect against IR injury in several organs, suggesting a role for COX in the modulation of IR injury in these organs. Hence, this study aimed to determine whether the administration of either ACE or MFA has a hepatoprotective effect against IR injury in Wistar rats.
WebNov 22, 2024 · This work investigated the effect of thyroxine on the biogenesis and quality control system in rat heart mitochondria. In hyperthyroid rats, the concentrations of free triiodothyronine and thyroxine increased severalfold, indicating the development of hyperthyroidism in these animals. The electron microscopy showed 58% of cardiac …
WebJul 5, 2015 · The effects of etoricoxib on NO and 8-OHdG levels in rats (ETO-50: etoricoxib-50 mg group, ETO-100: etoricoxib-100 mg group, LIRC: liver ischemia … swedbank share repurchasesWebSome of the common and major side effects of Etoricoxib are: Flu; Indigestion; Stomach pain; Diarrhea; Peripheral edema; The most common side effects of Naproxen are: … skyscanner direct flightsWebWe investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). swedbank target priceWebSome of the common and major side effects of Etoricoxib are: Flu Indigestion Stomach pain Diarrhea Peripheral edema Flatulence Weakness Fatigue Nausea High blood pressure Irregular heartbeat Difficult while breathing Heart rhythm disorders Etoricoxib can cause some serious side effects and can lead to some serious health problems. swedbank t centralenWebApr 14, 2024 · Effects of losartan, metformin and glibenclamide on 2-hourly fasting blood sugar level of DOCA + STZ hypertensive diabetic rats. Table 2 shows the effects of LOS, MET and GLB on fasting blood sugar level (hourly) of DOCA + STZ-induced hypertensive diabetic rats. There was a significant (P < 0.05) increase in FBS level of the HD control … skyscanner egal wohinWebSep 29, 2024 · Table 1 Effect of CP and/or LC treatment on serum biochemical parameters in rats (n = 7). Hepatic and Renal Oxidative Damage Parameters In the present study, there was substantially increased in MDA level along with a dramatic decrease in GSH and CAT in the liver and kidney tissues of CP-intoxicated rats. swedberg contracting corpWebJun 16, 2015 · Figure 3. The effects of etoricoxib on NO and 8-OHdG levels in rats (ETO-50: etoricoxib-50 mg group, ETO-100: etoricoxib-100 mg group, LIRC: liver ischemia reperfusion control group, and HG: healthy group, ). Etoricoxib at the same doses also suppressed increase of the amount of 8-OH/Gua which is a product of DNA damage. swedbank support