Cisplatin hplc
WebJul 13, 2015 · Cisplatin is one of the first-choice drugs for the treatment of many cancers but it is not without its disadvantages, principally toxicity to the liver, kidney, brain and gastrointestinal tract, the initiation of hearing loss, and suppression of bone marrow. WebA potent platinum-based antineoplastic drug. Its mode of action involves formation of inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I. Cisplatin synergizes with a variety of anticancer agents.
Cisplatin hplc
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WebNov 1, 2008 · We found that AGT is readily cross-linked to DNA in the presence of cisplatin. HPLC-ESI⁺-MS/MS sequencing of tryptic peptides originating from dG-Pt-AGT complexes revealed that the cross-linking ... WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent …
WebThe platinum content (4.91%) of Polycisplatin was determined by modified HPLC–UV method detailed in the literature. 19 Briefly, a known amount of Polycisplatin was dissolved in 0.5 M HCl solution and stirred so as to cleave the AA-Pt bond and release the cisplatin. The cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and ... WebMay 23, 2024 · Cisplatin (Figure 1) belongs to an alkylating class of anticancer drugs and is the first member of platinum containing drugs used as antineoplastic in early 1970’s. It is a divalent inorganic, water soluble platinum containing complex and is widely used due to its potent effects in the treatment of ovarian, testicular,
WebEnter the email address you signed up with and we'll email you a reset link. Webneeded. As cisplatin is a metal-based molecule, historical analyses include phosphorescence, high-performance liquid chromatography with ultraviolet visible …
WebGemcitabine (Gem) and cisplatin (Cis) are currently being used for lung cancer treatment, but they are highly toxic in high dosages. This research aimed to develop a niosome formulation...
WebCisplatin is an antineoplastic drug used for the treatment of cancer patients with a variety of different malignancies. Application Cisplatin may be used as an analytical reference standard for the determination of the analyte in plasma, cancer cell, and tumor samples by high-performance liquid chromatographic assay. birmingham fresh food marketWebA high-performance liquid chromatographic (HPLC) method is described for the determination of residual levels of cisplatin from extracts of surfaces with very low surface area; from extracts of surfaces of coupons made of Teflon (polytetrafluoroethylene, PTFE), stainless steel, and glass; and in aqu … danesha couch jeffery presslerWebMar 1, 2024 · Cisplatin is a platinum containing compound used for the treatment of different types of cancers. Quantitative determination of cisplatin has been carried out using atomic absorption spectroscopy, high pressure liquid chromatography with phosphorescence, ultra-violet detection, or with inductively coupled plasma mass … danesha flowersWebSep 18, 2024 · National Center for Biotechnology Information birmingham funeral homeWebHPLC is a useful technique for monitoring 2 and 3, but only if the components of the mobile phase used in the reverse phase HPLC technique are unreactive toward these aqua complexes under the conditions of the experiment. 15N Nuclear magnetic resonance (NMR) with samples highly enriched (>98%) in 15N has been used to check the reactivity of 2 … danesh aestheticsWebAug 15, 2007 · Paclitaxel and platinum analogs (cisplatin and carboplatin) is one such FDA approved combination administered sequentially for the treatment of different types of cancers; for example carboplatin in combination with paclitaxel is an approved therapy in patients with non small cell lung cancer (NSCLC), advanced and recurrent cervical … birmingham funeral home in vienna mobirmingham funeral home maine